08-P006 The Caenorhabditis elegans nuclear receptor NHR-25 controls epidermal T cell differentiation
نویسندگان
چکیده
manipulating spindle by laser, we showed that the spindle asymmetry is essential for asymmetric nuclear localization of b-catenin. Because a kinesin inhibitor disrupted asymmetry of b-catenin localization, we propose that kinesin dependent transport of b-catenin along astral microtubules causes the enhancement of nuclear b-catenin export. This process occurs more efficiently in the anterior side that has more astral microtubules, resulting in asymmetric nuclear localization of b-catenin. Our results show a novel mechanism of b-catenin nuclear localization regulated by spindle. We will discuss how cortical proteins regulate the asymmetric spindle structure.
منابع مشابه
Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans.
Epithelial cell shape changes underlie important events in animal development. During the postembryonic life of the nematode Caenorhabditis elegans, stem epidermal seam cells lose and actively renew mutual adherens junction contacts after each asymmetric division that separates them. The seam cell contacts are important for epidermal differentiation, but what regulates the cell-shape changes th...
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عنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009